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Challenges in Assigning Endocrine-Specific Modes of Action: Recommendations for Researchers and Regulators

Challenges in Assigning Endocrine-Specific Modes of Action: Recommendations for Researchers and Regulators

by Michael Boyd | Jul 25, 2023 | Publications

Because regulatory programs evaluate substances for their endocrine-disrupting properties, careful study design and data interpretation are needed to distinguish between responses that are truly endocrine specific and those that are not. This is particularly important...
Hypothesis-driven weight-of-evidence analysis of endocrine disruption potential: a case study with triclosan

Hypothesis-driven weight-of-evidence analysis of endocrine disruption potential: a case study with triclosan

by Michael Boyd | Jul 25, 2023 | Publications

Triclosan is an antimicrobial agent used in a range of consumer products, such as deodorants, oral care, clothing, and household items. As with many consumer products, triclosan can be rinsed down the drain and transported to wastewater treatment plants. While most is...
Potency Matters: Thresholds Govern Endocrine Activity

Potency Matters: Thresholds Govern Endocrine Activity

by Michael Boyd | Jul 25, 2023 | Publications

Whether thresholds exist for endocrine active substances and for endocrine disrupting effects of exogenous chemicals has been posed as a question for regulatory policy by the European Union. This question arises from a concern that the endocrine system is too complex...
Potency Matters: Thresholds Govern Endocrine Activity

Analysis of EPA’s endocrine screening battery and recommendations for further review

by Michael Boyd | Jul 25, 2023 | Publications

The Epidemiologic Evidence Linking Prenatal and Postnatal Exposure to Endocrine Disrupting Chemicals with Male Reproductive Disorders: A Systematic Review and Meta-Analysis

The Epidemiologic Evidence Linking Prenatal and Postnatal Exposure to Endocrine Disrupting Chemicals with Male Reproductive Disorders: A Systematic Review and Meta-Analysis

by Michael Boyd | Jul 25, 2023 | Publications

The literature search resulted in 1314 references among which we identified 33 papers(28 study populations) fulfilling the eligibility criteria. These provided 85 risk estimates of links between persistent organic pollutants and rapidly metabolized compounds...
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