Critical Analysis of the Key Characteristics Approach

Recently, a new approach for identifying EDC hazards has been proposed that organizes and evaluates data according to ten so-called “Key Characteristics (KCs) of EDCs.” It claims to address the lack of a widely accepted, systematic approach for identifying “EDC hazards,” but it fails validation tests and completely ignores the extensive literature on Weight of Evidence (WoE) methods for evaluating EDCs.

Upcoming Spotlight:

Potency Thresholds for EDCs

The pharmacological principle of potency is central to evaluating EDCs. 

This Spotlight will explain the basis for and validation of potency thresholds for identifying EDCs.



We answer clinician questions with evidence-based science.


We furnish scientists with evidence-based resources on endocrine disrupting chemicals and their effects on humans or wildlife.


We provide helpful guides outlining principles, processes, and programs for regulating endocrine-active chemicals.

ABOUT The Endocrine Policy Forum

The Endocrine Policy Forum (EPF) is a consortium of scientific and regulatory experts coordinating industry participation in the U.S. Environmental Protection Agency’s efforts to screen chemicals for endocrine activity. EPF’s mission is to bring balanced, science- and risk-based analysis to scientists, medical professionals and regulators in the U.S. and beyond to ensure chemicals are properly screened, tested and regulated for endocrine activity and the potential to cause adverse health effects.