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Issue analysis: key characteristics approach for identifying endocrine disruptors

by Christopher Borgert | Oct 5, 2023 | Publications

The approach claims to address the lack of a widely accepted, systematic approach for identifying EDC hazards, but completely ignores the WoE literature for EDCs. In contrast to WoE methods, the KC approach fails to apply the consensus definition of EDC and is not...

Current Limitations and Recommendations to Improve Testing for the Environmental Assessment of Endocrine Active Substances

by Michael Boyd | Aug 7, 2023 | Publications

Regulatory frameworks vary somewhat across geographies, but all basically evaluate whether a chemical possesses endocrine activity and whether this activity can result in adverse outcomes either to humans or to the environment. Current test systems include in silico,...

Challenges and Approaches to Conducting and Interpreting the Amphibian Metamorphosis Assay and the Fish Short-Term Reproduction Assay

by Michael Boyd | Aug 7, 2023 | Publications

Various approaches are described for addressing the challenges associated with both the conduct and interpretation of these assays. Historical control data for both the AMA and FSTRA are presented to further understand background occurrences of histopathological...

An appeal for the integrity of science and public policy

by Michael Boyd | Aug 7, 2023 | Publications

Human-relevant potency threshold (HRPT) for ERα agonism

Human-relevant potency threshold (HRPT) for ERα agonism

by Michael Boyd | Jul 25, 2023 | Publications

The European Commission has recently proposed draft criteria for the identification of endocrine disrupting chemicals (EDCs) that pose a significant hazard to humans or the environment. Identifying and characterizing toxic hazards based on the manner by which adverse...
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