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Video: Mission of the Endocrine Policy Forum

Video: Mission of the Endocrine Policy Forum

by Michael Boyd | Jul 25, 2023 | Videos

Human cost burden of exposure to EDCs. A critical review

Human cost burden of exposure to EDCs. A critical review

by Michael Boyd | Jul 25, 2023 | Publications

Since the vast majority of their assigned disease burden costs are driven by the assumption that “loss of IQ” and “increased prevalence of intellectual disability” are caused by exposures to organophosphate pesticides (OPPs) and brominated flame retardants (PBDEs), we...
Hypothesis-driven weight of evidence framework for evaluating data within the US EPA’s Endocrine Disruptor Screening Program

Hypothesis-driven weight of evidence framework for evaluating data within the US EPA’s Endocrine Disruptor Screening Program

by Michael Boyd | Jul 25, 2023 | Publications

Published recommendations are used to evaluate data validity for testing each hypothesis and quantitative weightings are proposed to reflect two data parameters. Relevance weightings should be derived for each endpoint to reflect the degree to which it probes each...
Relevance Weighting of Tier 1 Endocrine Screening Endpoints by Rank Order

Relevance Weighting of Tier 1 Endocrine Screening Endpoints by Rank Order

by Michael Boyd | Jul 25, 2023 | Publications

Rank 1 was assigned to in vivo endpoints that characterize the fundamental physiological actions for androgen, estrogen, and thyroid activities. Rank 1 endpoints are specific and sensitive for the hypothesis, interpretable without ancillary data, and rarely confounded...
Hypothesis-driven WoE analysis to determine potential endocrine activity of MTBE

Hypothesis-driven WoE analysis to determine potential endocrine activity of MTBE

by Michael Boyd | Jul 25, 2023 | Publications

Resolving whether MTBE exhibits endocrine activity is important given regulatory and public interest in endocrine disrupting substances and their potential for causing adverse effects in humans or wildlife. A weight-of-evidence (WoE) analysis was conducted, focusing...
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