Spotlight Archives - Endocrine Policy Forum

Reproduction of the human relevant potency threshold (HRPT) for estrogen receptor alpha agonism in an inference performance screen for ICCVAM’s regulatory scientific confidence framework

by Susan Borgert | Oct 16, 2025 | Publications

Ryman & Becker 2025

How well can carcinogenicity be predicted by high throughput “characteristics of carcinogens” mechanistic data?

by Susan Borgert | Aug 6, 2025 | Publications

The physiological and biochemical basis of potency thresholds modeled using human estrogen receptor alpha: implications for identifying endocrine disruptors

by Susan Borgert | Aug 6, 2025 | Publications

Beyond key characteristics of carcinogens: an archetypal MOA-based evidence system for hypothesis testing to advance carcinogen risk assessment

by Susan Borgert | Aug 6, 2025 | Publications

Critical Analysis of the Consensus Key Characteristics Approach

by Susan Borgert | Apr 17, 2024 | Presentations

This analysis shows that application of the CKCA finds evidence that water, calcium, sodium, glutathione, adenosine triphosphate (ATP) and linoleic acid – which are all natural substances essential for life – are all carcinogens and EDCs, yet, those substances are...

Reproduction of the human relevant potency threshold (HRPT) for estrogen receptor alpha agonism in an inference performance screen for ICCVAM’s regulatory scientific confidence framework

How well can carcinogenicity be predicted by high throughput “characteristics of carcinogens” mechanistic data?

The physiological and biochemical basis of potency thresholds modeled using human estrogen receptor alpha: implications for identifying endocrine disruptors

Beyond key characteristics of carcinogens: an archetypal MOA-based evidence system for hypothesis testing to advance carcinogen risk assessment

Critical Analysis of the Consensus Key Characteristics Approach

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