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Key Learnings from the Endocrine Disruptor Screening Program (EDSP) Tier 1 Rodent Uterotrophic and Hershberger Assays

Key Learnings from the Endocrine Disruptor Screening Program (EDSP) Tier 1 Rodent Uterotrophic and Hershberger Assays

by Michael Boyd | Jul 25, 2023 | Publications

In 2009, companies began screening compounds using the US Environmental Protection Agency’s Endocrine Disruptor Screening Program (EDSP). EDSP has two tiers: Tier 1 includes 11 assays to identify compounds with potential endocrine activity. This article...
Limitations, uncertainties and competing interpretations regarding chemical exposures and diabetes

Limitations, uncertainties and competing interpretations regarding chemical exposures and diabetes

by Michael Boyd | Jul 25, 2023 | Publications

Population-Relevant Endpoints in the Evaluation of Endocrine-Active Substances (EAS) for Ecotoxicological Hazard and Risk Assessment

Population-Relevant Endpoints in the Evaluation of Endocrine-Active Substances (EAS) for Ecotoxicological Hazard and Risk Assessment

by Michael Boyd | Jul 25, 2023 | Publications

A wide variety of potentially endocrine-relevant endpoints were identified for mollusks, fish, amphibians, birds, and mammals, although the strength of the relationship between test endpoints and population-level effects was often uncertain. Furthermore, testing alone...
Challenges in Assigning Endocrine-Specific Modes of Action: Recommendations for Researchers and Regulators

Challenges in Assigning Endocrine-Specific Modes of Action: Recommendations for Researchers and Regulators

by Michael Boyd | Jul 25, 2023 | Publications

Because regulatory programs evaluate substances for their endocrine-disrupting properties, careful study design and data interpretation are needed to distinguish between responses that are truly endocrine specific and those that are not. This is particularly important...
Hypothesis-driven weight-of-evidence analysis of endocrine disruption potential: a case study with triclosan

Hypothesis-driven weight-of-evidence analysis of endocrine disruption potential: a case study with triclosan

by Michael Boyd | Jul 25, 2023 | Publications

Triclosan is an antimicrobial agent used in a range of consumer products, such as deodorants, oral care, clothing, and household items. As with many consumer products, triclosan can be rinsed down the drain and transported to wastewater treatment plants. While most is...
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